MolGen is a research group at the university of Groningen, the Netherlands. Our main focus is on the molecular genetics and system biology of Gram-positive bacteria; Bacillus subtilis, Lactococcus lactis, Bacillus cereus, Streptococcus pneumoniae and Enterococcus faecalis. The nature of the research is both fundamental and application oriented. Large data sets generated by transcriptomics and proteomics studies are analyzed and new bioinformatics tools are developed.
PePPER: a web based regulon, TF and TFBS mining system
PePPER (Prediction of Prokaryote Promoter Elements and Regulons) is a system for combining, predicting and mining for TFBSs and regulons.
PePPER currently predicts detailed information on promoters, terminators, ribosomal binding sites, and TFBSs. This webserver offers an all-in-one mining tool to discover regulons and TFBSs (Transcription Factor Binding Sites) in prokaryotes. The regulon and TFBS database used by PePPER is based on DBTBS, RegulonDB and MolgenRegDB. Furthermore, this webserver offers an improved promoter prediction algorithm for prokaryotes. Other individual bioinformatics tools used for comparative genomics, transcription terminator prediction and DNA motif mining are integrated in this webserver. Finally, results will be presented in clear tables and graphics. (updated: 03-03-2011)
Developed by Anne de Jong, with special thanks to Hilco Pietersma and Martijn Cordes
Department of Molecular Genetics
Groningen Biomolecular Sciences and Biotechnology Institute (GBB)
university of Groningen
9747 AG Groningen
Group leaders of our Department:
Prof. Dr. O.P. Kuipers (phone +31 50 363 2093)
Prof. Dr. J. Kok (phone +31 50 363 2111)